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are posted on the website.Generalized reaction scheme to describe the solvent effect on reaction of P6+, P6- with halogen atoms.
A new type of electronic scheme to describe the solvent effect on reaction of P6+, P6- with halogen atoms is proposed and tested for halogen atom abstraction from P6+ and P6- by Br(-) and I(-) with B3LYP/6-311G** method. It is found that the solvent effect can be described reasonably in this case, and the solvent effect on the reaction of P6+ and P6- with Br(-) is weaker than that on the reaction of P6+ and P6- with I(-) due to the substitution effects of bromide ion. The solvent effect on the reaction of P6+ and P6- with Br(-), P6+ and P6- with I(-) is analyzed in detail by Bader charge analysis.Immunologic and clinical implications of the F1 allele of coagulation Factor 1.
Fibrinogen as a plasma protein has a well-established participation in a number of physiologic and pathologic processes, such as blood coagulation, platelet aggregation, host defense, and wound healing. The relationship of fibrinogen genetics and its structure to the proposed involvement of fibrinogen in the immunologic response has not been established. The F1 allele of coagulation Factor 1 (F1) has previously been described as a fibrinogen variant that differs from the normal protein by an amino acid change in the central A alpha chain (H402Q). H402 is conserved among all F1 isotypes, suggesting it may play an important role in coagulation Factor 1 function. In this study, there were no differences in prothrombin time, activated partial thromb
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